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There are a large number of B vitamins all involved in the process of the metabolism of living cells. Working with proteins, they serve as coenzymes in the various enzyme systems of the body. B vitamins must be replaced regularly because they are water-soluble and are not stored in the body to any extent. Because B vitamins work together synergistically, insufficient intake of one or more B vitamins can hamper the utilization of others, causing an imbalance to occur.